Blender installs natively from Steam and works without any emulation of windows' stuff. I noticed the download size is different for Linux, so I guess they cared to pack everything needed for it to work smoothly.

Some distro claimed they did everything to make UX with Resolve one of their targets, I believe it's Nobara or maybe Bazzite. It's not emulated either and installers are also provided by the devs of Resolve themselves.

Affinity have no plans to make a Linux version, so it's always emulated and has workarounds like that (github) but I haven't used their software even on Windows so Idk how the experience of using their products is. Coming to Linux, I got used to Inkscape for my vector needs and Krita\Photopea for raster gfx. I heard Darktable is a good Lightroom alternative if it's up your valley.