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Not me, but my wife.
She trained and worked as an optometrist. She absolutely loved it, but she started having health problems and after about 10-15 years in practice she had to give it up.
It's been very slow in developing, but it's starting to look like a progressive neurological disorder. She can't work, and she can't drive anywhere. She can still walk around the house, or down to the corner, but the more she does the more pain she feels, and if she does too much, then she won't be able to move.
Medical appointments are almost the only thing she leaves the house for, and it's starting to affect her memory and ability to communicate (difficulty coming up with words).
She's feels disconnected from the world. After our last child moved out for college, we got a could guinea pigs and she takes care of them for the most part.
She also feels guilty since she can't earn money. She had private disability insurance which covers her until 65, and she gets social security, but it all amounts to a fraction of what she could be making as an eye doctor.
She also has trouble staying involved in conversations, and I think she's more sensitive to that than she used to be.