I think the primary differentiating factor will just be the nature of the world. 16 quintillion planets is going to feel WAY different than 1 massive one. HG also implied that LNF will be an MMO - something I, frankly, still have a hard time believing given NMS's network issues, but I can't imagine they'd overpromise again.

"Hello Games is procedurally generating just a single instance of this planet, one which every player (and everything the build, discover, and name) will exist on simultaneously." - GamesRadar