Eh, I usually pick up on relatively subtle cues, I just have trouble interpreting them. I can tell they're flirting, I just don't know if they're doing it because they're interested in me, or they just want something from me (better service, helpful directions, or material to laugh about later w/ friends). So even if I pick up on it, I'm unlikely to actually act differently until I have verbal confirmation.

This causes some issues w/ my wife, so I try to reassure her that I understand she's frustrated or whatever, but that I'm unsure what she's expecting me to do about it (is she looking to vent or does she want me to problem-solve). This occasionally pisses her off (why can't you tell what I want?!?), but she usually realizes that I have a valid reason to be confused and is more direct after a bit of time thinking about it.

Communication is absolutely key in any kind of relationship, and that goes both ways. I don't think I'm autistic (wouldn't be surprised if I'm at the mild end of the spectrum though), but I do appreciate confirmation of certain social cues.