LibreOffice has opened every DOC(X) the school has sent me, albeit imperfectly, and all assignments are turned in as PDFs, which I usually make using Markdown and LaTeX. I have had to use Office 365 for collaboration, but only about twice a year, and that runs very smoothly in Firefox. On one occasion I tried to collaborate with CryptPad, but it didn't work as well as I hoped.
Most computer labs at my uni run Windows 10, rarely 11, but a lot of the science labs run Linux. A surprising amount of the software required for classes has been open-source, too.
The most frustrating thing has been the lockdown browser used for some exams. My university library has computers I can borrow for exams, but yours might not, and they detect VMs, so you might have to dual boot for that.
Going by their Mastodon account, seems they were erroneously detected as "from a US-sanctioned region" and it took too long for said error to be resolved, so they just made the switch.