If you read the article, it does not say there has been a second wave or something targetting LGTBQ+ games. It is one person saying their comic was SFW and was delisted.
We should definitely fight back regardless, don't get me wrong, but as of yet there has not been LGBTQ+ targetting.
The author of the SFW comic should contact itchio and ask why their game was deindexed, since itch did MASSIVE removal of all "adult" and NSFW content beyond what their payment processors asked, as to evade any issue and then reindex according to them.
Again, we should be alert, and we should monitor their firther actions closely, but it's not time yet to cry wolf with the LGBTQ+ targetting.
I work IT... how exactly are they blocking wireguard?
Edit: Okay, I did the search, and as I guessed, they do not. Users seem to report UDP blocking and throttling in general, not wireguard (I'm not sure that would be possible). It's not even particularly confirmed though.