1
submitted 1 year ago by karce@wizanons.dev to c/magic@wizanons.dev

Psychedelics are a broad class of drugs defined by their ability to induce an altered state of consciousness. These drugs have been used for millennia in both spiritual and medicinal contexts, and a number of recent clinical successes have spurred a renewed interest in developing psychedelic therapies. Nevertheless, a unifying mechanism that can account for these shared phenomenological and therapeutic properties remains unknown. Here we demonstrate in mice that the ability to reopen the social reward learning critical period is a shared property across psychedelic drugs. Notably, the time course of critical period reopening is proportional to the duration of acute subjective effects reported in humans. Furthermore, the ability to reinstate social reward learning in adulthood is paralleled by metaplastic restoration of oxytocin-mediated long-term depression in the nucleus accumbens. Finally, identification of differentially expressed genes in the ‘open state’ versus the ‘closed state’ provides evidence that reorganization of the extracellular matrix is a common downstream mechanism underlying psychedelic drug-mediated critical period reopening. Together these results have important implications for the implementation of psychedelics in clinical practice, as well as the design of novel compounds for the treatment of neuropsychiatric disease.

no comments (yet)
sorted by: hot top controversial new old
there doesn't seem to be anything here
this post was submitted on 15 Jun 2023
1 points (100.0% liked)

Magic

3 readers
1 users here now

Magic, Mysticism, and Psychedelics!

Psychonauts welcome!

Discussion on Psilocybin Mushrooms, LSD, MDMA, Mescaline, DMT, and Ayahuasca. News on therapies very encouraged!

Rules:

  1. Be nice, I want to encourage playful safe spaces.
  2. No sourcing, It's illegal in the US.

founded 1 year ago
MODERATORS