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A ketogenic diet promotes tumour growth in the small intestine in susceptible mice. In people, diet advice might need to be tailored to individual cancer risks.

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[-] dbtng@sh.itjust.works 12 points 4 days ago

Judging from the comments, people are committed to their atkins thing.
I don't expect this to be well received.

Fiber. You need it. This 'ketogenic' thing is suicide.

[-] IronBird@lemmy.world 12 points 4 days ago

you can eat plenty of fiber and still be keto

[-] psud@aussie.zone 3 points 4 days ago

Also you can eat none and be perfectly healthy

[-] psud@aussie.zone 3 points 4 days ago

Can you point to research that says we require fibre?

[-] dbtng@sh.itjust.works 11 points 4 days ago

I guess you are kidding, but sure. It's good to get the info out there. All ya gotta do is google it tho ...

Would you prefer Stanford, Harvard, Mayo Clinic, or NIH?

[-] psud@aussie.zone 3 points 4 days ago

I mean a paper that is not an epidemiological one (as they have no ability to show cause and effect) that shows you die without fibre after however long without it

Like life without vitamin C or its precursor goes on for a couple of months then symptoms get serious and you die of scurvy

What's the time limit on fibre?

[-] dbtng@sh.itjust.works 10 points 4 days ago

Well, for me it was about 42 years, till I was bleeding out my ass all the time.
You know, some of us are hard to convince.
I'm cured, but I'll require regular colonoscopies for the rest of my life.

I'll see you at the butt doctor when it hits you too. Or ... you could act sensibly. Now.

[-] psud@aussie.zone 3 points 4 days ago

That's pretty funny, I know it's not true though as a no fibre diet for that long has to be very high fat and I've read a lot about low fibre high fat diets that I know that make shitting easy

[-] dbtng@sh.itjust.works 4 points 4 days ago

Shitting was not a problem. Shitting blood was the issue.
Your gut bugs need fiber to eat. Or they will eventually eat you.
You cannot maintain a healthy microbiome without fiber.
The older you get, the less your guts can tolerate the type of self-abuse you are pushing here.
Additionally, fiber consumption has a dramatic impact on cholesterol processing. That's actually what finally brought me to the table for a balanced meal.

[-] psud@aussie.zone 3 points 4 days ago

Ah, your story was trying to build up to "fibre is vital" the only studies of fibre on constipation and straining on the toilet showed fibre increased both, reducing fibre improved both, eliminating fibre completely fixed both

The comparison that one made was "adding fibre to improve constipation is like adding cars to improve traffic"

[-] dbtng@sh.itjust.works 4 points 4 days ago

Ya, that's never been a problem for me. I think the 'bad thing' was dental infections and a bunch of antibiotics. That threw my shitter out of kilter and made me understand you have to manage your gut like a garden. When you see that bright red blood in the bowl, you realize change is in order and start listening to doctors instead of diet fads and 'your own research'.

[-] psud@aussie.zone 3 points 4 days ago

That's what happens when you eat too much sugar

[-] dbtng@sh.itjust.works 2 points 4 days ago

I would not argue that point, but ... its beside the point.

[-] xep@discuss.online 2 points 4 days ago

If we're doing n=1 anecdotes, removing fibre from my diet cured my constipation.

[-] psud@aussie.zone 3 points 4 days ago
[-] Atelopus-zeteki@fedia.io 1 points 3 days ago

Is xep your other account? Just curious.

[-] psud@aussie.zone 3 points 3 days ago* (last edited 3 days ago)

No. Xep is in a different timezone than me and doesn't have as good English. All my accounts are named psud or pseudopsud. I have three accounts as I have had bad luck with instances.

I try not to post or comment under my other logins - when Aussie.zone is down I just read, otherwise I'd get replies I wouldn't see for months

[-] THE_GR8_MIKE@lemmy.world 14 points 4 days ago

What about a high fat high carb diet?

Obesity is linked to higher risk for many cancers

[-] psud@aussie.zone 4 points 4 days ago

That'll make you fat and bring on metabolic syndrome and all that

[-] hakunawazo@lemmy.world 5 points 4 days ago* (last edited 4 days ago)

...asking for a very unhealthy friend...uhm...

[-] P00ptart@lemmy.world 4 points 4 days ago* (last edited 4 days ago)

As long as it's high in saturated fats and simple carbs, you'll be fine. But don't do anything physically demanding, or could be considered exercise.

[-] medem@lemmy.wtf 2 points 4 days ago

Didn't you mean complex carbs?

[-] xep@discuss.online 2 points 4 days ago

But don’t do anything physically demanding, or could be considered exercise.

He's joking.

[-] P00ptart@lemmy.world 3 points 4 days ago

Complex carbs are like corn and potatoes. They break down slower and give you more energy over time. They're not super great but simple carbs are like white bread and candy, which spike energy and blood sugar levels.

It’s almost as if the most healthy diet is a diverse one.

[-] psud@aussie.zone 4 points 4 days ago* (last edited 4 days ago)

What were the mice fed? Is this like a vegetarian low carb diet where the fats come from factory fats - seed oils?

Does "susceptible mice" mean mice that are highly prone to cancer?

Were they also fed carcinogens?

There is reason to think that high meat, high animal fat diets are protective against cancer, as cancer depends on sugar

[-] jet@hackertalks.com 5 points 4 days ago

What were the mice fed? Is this like a vegetarian low carb diet where the fats come from factory fats - seed oils?

this was the diet used https://researchdiets.com/en/formulas/d06040601 sucrose, corn starch, soybean oil, food dyes... you know... keto stuff.... 6% daily energy from soybean oil

Were they also fed carcinogens?

the mice were genetically engineered to develop tumors, so not fed, designed.

There is reason to think that high meat, high animal fat diets are protective against cancer, as cancer depends on sugar

This study isn't about keto, its about the pathway of tumor growth in genetically engineered tumor laden mice in a high fat diet.... unless your a mouse engineered to develop tumors genetically this doesn't apply to you.

[-] psud@aussie.zone 3 points 4 days ago

So these mice were on a high carb diet with exogenous ketones? 6% energy from fat isn't ketogenic

[-] jet@hackertalks.com 3 points 4 days ago

6% from soybean oil, total energy from fat was about 80%, except they didn't count fibre in the diet as carbohydrates... if you do that its a 15% carb diet.

[-] psud@aussie.zone 2 points 4 days ago* (last edited 4 days ago)

I don't tolerate sugar or fibre well, and I'll avoid plant oils in general

[-] psud@aussie.zone 3 points 4 days ago

Ok so I'm not a mouse, I'm not from a line deliberately bred for cancer, and my diet has none of those things; my 80% energy from fat is from beef fat. I think I'm not going to worry about this

[-] jet@hackertalks.com 3 points 4 days ago

also 50g of fibre in the feed diet, maybe the tumors are responding to fibre?

i'm just skimming right now, but the papers studies each used 2-4 mice, and are not powered at all. it's hard to say even if you WERE a PPAR-CPT1A engineered mouse that these results are relevant... they knocked out ketogenesis in a few of the mice and still saw tumor growth.... let's not forget the genetic engineering here not only induces tumors, but also suppresses bhb production... so maybe these tumors respond well to fatty acids, but would be suppressed by healthy bhb production and ketone metabolism... this paper doesn't know. it's possible the net effect of a healthy ketogenic metabolism would be enough in non-genetically engineered mice to reduce the tumors.... they didn't test that.

plus...... they didn't measure all cause mortality! so we just know tumor growth for a window... why not actually get all cause mortality data? nothing ruins short term results like long term data.

the fact we have human interventional studies directly linking tumor growth to glucose intake, and in this mice study we see the opposite only in their genetically engineered tumors.... i'm not sure we can make any meaningful conclusions from that.

[-] psud@aussie.zone 3 points 4 days ago

They conclude the cancers are triggered by the fats not ketones based on the study title (I haven't had time to read the study yet)

[-] jet@hackertalks.com 4 points 4 days ago* (last edited 4 days ago)

the study isn't open access, I'm pretty sure nobody has read the study including the nature "article" author.

it's pretty bad form, and intellectually dishonest, to share a paywalled article on a paywalled paper, just because you like the title... ensuring nobody will read what is actually said is pretty anti-science.

this post was submitted on 16 Jul 2026
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