If running a windows game through wine, there are some risks if the game contains a virus.
The biggest risk is that wine typically makes your Linux user files available by having them mounted as the z: drive. If you run an exe that's actually ransomware, it can possibly encrypt some of your userfiles if permissions allow. This isn't an issue if you run the games through steam, because it runs windows programs in containers.
There's also a risk of keyloggers, but they should only work for things running inside the same wine session.



