The main issue is that SteamOS Beta updates frequently break Decky loader, but it's rarely an issue if you're on stable. The worst issues I know of with plugins were IsThereAnyDeal plugin was causing performance issues, and DeckyRecorder was causing some decks to be unable to switch to desktop mode.
Overall though it's rare to have serious issues from Decky, especially on stable SteamOS. You may not want to install a bunch of unnecessary plugins that you won't ever use, but you shouldn't hesitate to use any that meet your needs. If you ever have steamOS issues (crashing/etc) you will want to disable decky and see if that fixes it before you contact Valve though.