Microbial ecosystems are fundamental to planetary and human health, yet human activities are accelerating their loss. Disruptions to microbial communities undermine environmental stability, biodiversity, and health. Urgent action is required to preserve microbial diversity.

The Microbiota Vault Initiative provides a global framework to safeguard microbiomes from human, animal, and environmental sources. It proactively archives microbial diversity for future needs, prioritizing depositor sovereignty, equitable collaboration, and ethical governance.

By sharing limited information on deposits, the initiative fosters microbial conservation and collaboration between local and global researchers. It complements other efforts to ensure the resilience of microbiomes in an era of rapid environmental change.