I think something like strength 4, with maxed out or nearly maxed out luck, intelligence, and agility is very powerful. You can increase every skill by one, and if you take gambling all of the skills except luck will be trivial to purchase, but the opportunity only appears midgame.

Depending on what you want to do tagging gambling can be game breaking since once it’s high enough to statistically win you can go into a casino and win as much money as you want.

High luck gives you more special encounters. The alien blaster is good but I think the Red Ryder BB gun is even better. Important- the version of the gun in the locked container is a decoy, that’s not the good one. The good version of the BB gun with high luck and small gun skill can one-shot super mutants with critical hits.

After that, you can go high science if you want to talk the master to death, or high speech for more speech check wins, or lockpick skill to get more items (though with gambling this is largely unneeded).