If you referring to GUIs:

• GTK for Python: https://www.gtk.org/docs/language-bindings/python/

• Qt for Python: https://www.qt.io/qt-for-python

If you mean making an executable that can run without separately installing a Python interpreter or PyPi dependencies, there are Python packagers like Pyinstaller: https://pyinstaller.readthedocs.io/en/stable/