If you referring to GUIs:

• GTK for Python: https://www.gtk.org/docs/language-bindings/python/

• Qt for Python: https://www.qt.io/qt-for-python

If you mean making an executable that can run without separately installing a Python interpreter or PyPi dependencies, there are Python packagers like Pyinstaller: https://pyinstaller.readthedocs.io/en/stable/

I had been scrolling Mastodon timeline and found Flet - a framework for writing Flutter apps in Python.

Though I haven't tried it yet, it could be interesting and useful for you.

Links:

• https://flet.dev/
• https://github.com/flet-dev/flet