Muldraugh? I guess it has to be somewhat small, it sure feels like it when it's full of zombies

Jackman, Maine. Went once, not a very interesting place, about 1000 people there, in the middle of fucking nowhere

Alabama

Joshua Tree

i've been to the USA once so this might not count... but i think i knew "Salem" before visiting the US (but did not visit Salem though) so it might as well count.

However very long after knowing Salem exists i saw a documentation about something in the area that possibly caused halluzinations in the peoples minds, the documentation suggested this was a likely cause for the cities history, but those effects were why i knew about Salem in the first place. i don't remember what it was, think some plant, but don't remember exactly.

however this is the smallest city i could name in the reagion you asked for.

well, but: I don't see a geopolitical isolation there, they even want to build walls to start isolating themselves. and i don't see anything unique in that situation either. newzealand, iceland, madagasca just to name a few are more isolated geopolitically and much more unique in so many ways too.

could you help me to see the geopolicically isolation and uniqueness you are talking about?

Ablaquerqueueue?