You can, but I don't think it is necessary in most cases. Managing dependencies is one of the things that Nix is best at. You don't need to compile the software with Nix, but you can use a Nix shell to hack on some software without Nixifying it before hand. Shell's should make all of the dependencies you specify available to use, as well as setting the right environment variables to work without Nixifying. I only use distrobox if I run into some software that I have significant trouble running on NixOS with a shell, which rarely happens.