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YouTube's next move might make it virtually impossible to block ads
(www.androidpolice.com)
This is a most excellent place for technology news and articles.
If the YouTube interface restricts you skipping during certain parts of the video, an ad blocker can detect that and skip over it anyway. Otherwise, I myself will just skip over the ad.
Or at the very least detect when you can't skip and mute the tab and put a black box over top of the video.