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YouTube's next move might make it virtually impossible to block ads
(www.androidpolice.com)
This is a most excellent place for technology news and articles.
That sounds correct for me. It is possible for them to switch to a system where everyone can manually skip past the ad in the video stream but adblockers are useless (by not sending and indication of the ad to the client), but I don’t see that happening since most people don’t use adblockers and letting all of them easily skip past every ad is probably bad for profits.
There's already addons that can recognize in-video sponsored content and skip, if youtube splices in ads into the video stream these addons will still work (although depending on how strict server side logic is, they may have to pause when the buffer runs out until the time of the ad length has passed)