I personally run a ProxMox cluster. I run both Windows and Linux servers. I perform local full-VM backups using the hypervisor to a USB disk. That gives me a fast way to restore VMs if I need to. I also run Veeam, which handles the offsite copy and provides granular file restores. It's nice because the community edition supports hardened disk immutability, which can help prevent ransomware attacks and Unfortunate Incidents. That just runs over SSH, and installs a Veeam agent/repo on the remote linux box.

All linux.

Mostly running stuff directly, though I have some things in containers.

I've consolidated configs and such into just a few folders that I can bring over to a new system to get everything running again without losing anything.

This backup will likely only ever be needed in a catastrophic failure scenario where my local system is entirely lost.

Unless that happens, I already have enough redundancy locally to recover from any lesser mishaps.