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I have been trying to beat a 2nd run in Slay the Spire. I also have been failing to get past round 15 in that endless mode in Shotgun King: The Final Checkmate.
my advice is stack attack cards in act 1, while specializing for specific bosses. while that's going on, pay attention to relics or cards that might support a build/theme. the rest of the game, try to refine that theme to make it happen as reliably as possible.
also, speed is better then building up towards massive strength.