“Real analytical work” (I will take that to mean work people actually care about and may even pay good money for), is done with whatever does the job, on the given timeframe, and the analyst, researcher, or team are comfortable with. That may well be Excel. Or not. Depending on the task and people. But your audience will always care more for the appropriateness of your analytical approach for the given audience and task, and of course your results, rather than the tools you used to get there. Of course spreadsheets have limitations and one will do well to know them.