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Windows 12 May Require a Subscription
(www.pcmag.com)
This is a most excellent place for technology news and articles.
Short answer: no. You can expect to fiddle at least sometimes. Many games will run out of the box in proton, but there a million things that can throw a wrench in the gears. I've personally never had a 100% seamless experience for the duration of a game.
This has been true across a couple distros, although none that were specifically geared toward gaming. Maybe I'll change my tune next time I hop distros.
There's Valve's custom Distro they built for the steamdeck, unfortunately they haven't fully released it yet, for the time being it's only available via steamdeck recovery software.
I've heard that Mint, PopOS, and Manjaro are good for gaming, but I have not tried them myself. Mint is high on my list for my next distro.
I'm on Ubuntu 22.04 LTS now, which I chose in the hope that it would eliminate a lot of fiddling since it's a common, stable target officially supported by most companies (like Nvidia). Unfortunately, it is simply too old at this point.
I assume that if you are running AMD instead of Nvidia, you will have an easier time. Nvidia's drivers have been a pain point on every distro I've used.