So hopefully I'm doing this right! :) (I'm still new to some of this so haven't figured out things yet! I did ask this via Mastodon also, but wanted to add more detail to my answer!)
Is there a computer game, a moment in a game, a boss fight, or a specific moment that you would love to experience fresh with no prior memory of it?
Mine would have to be The Seat of Sacrifice fight in Final Fantasy XIV, one of if not my most favourite fights in the game to date.
The mechanics work so well and tie into everything that's been happening, and then that moment where <redacted> (I refuse to spoil it!) shows up to help and then leaves with I think what made me cheer SO MUCH the first time I did the fight.
The music, the song To The Edge has become one of my most played songs in my entire music library (alongside Endwalker - Footfalls and Shadowbringers) as it is quite frankly perfect for the fight. and when they revealed that Soken had been battling cancer and wrote it whilst in hospital...
I adore the fight all together, and cannot help but say the lines in the cut scene bit in the middle every time I do the fight, and will never ever get bored of it.
So what moments in a game would you love to complete again with no prior experience?
It's a recent one, but the first time I entered Giant's Deep in Outer Wilds. I have a pretty big fear/anxiety of the ocean and meteorological objects in large sizes (strange one but I feel sick and get vertigo looking up at large clouds). I also find gas giants to be eerie in general.
The first time entering the atmosphere I was sweating so hard, I had to take a shower. No horror game where the main intention is to scare me has ever given me that feeling before. I've only felt that kind of stress when I played RE Nemesis on the PS1 as a young child. The Jeff chapter in Half Life Alyx also came pretty close to that feeling.
I might be a masochist, because I want to experience that again.
Outer Wilds in general is a fantastic answer to this question since it relies so much on the knowledge you gain during your playthrough.