I find that Bottles is more like just setting up your own wine prefix and keeping it organized. I was a Lutris user for years, but switched to Bottles last year and never looked back.

It's more convenient than Lutris for installing adhoc games, or multiple games in one bottle. Don't get me wrong, when Lutris works out of the box it's great, but oftentimes there's no recipe on Lutris for a game (eg when they're relatively unknown or new games) or the recipe is severely dated.