biologics, not very simple as these are monoclonal antibody you need a vector to produce them in large vats, also because most of them are still under patent, hence the high cost. simple drugs like oral steroids, Rx histamine is easy to make. others like ORAL tacrolimus, siroliumus, other immunosuppresants are also someone hard to make. and india still makes alot of the generics, which are priced high still.