Any rough edges you’ve encountered yet?

No problems so far, but I didn't try anything USB-related. Two of the more interesting programs I use it actively for are Ubuntu distrobox for Ultimate Doom Builder (level editor, works with GPU) and toolbox for natpmpc (utility for port-forwarding). I made a systemd service on my host system that calls toolbox run natpmpc -a 1 0 tcp 60 -g "$GATEWAY" 2>/dev/null in a loop to establish port-forwarding for my ProtonVPN connection (running on the host ofc), parses the assigned port and calls qbittorrent's web api to set forwarded port there.