The issue inherent to it is when you have people giving seemingly literal agreement to satirical statements,

I will just take this at face value: what makes this an issue?

I don't know if my neighbor has double-locked their front door, should I go and check?

this discussion isn't just about visual shorthand of a comic, it has some amount of real world investment.

Yes, I am aware that jokes are political.

My reading is that this is yet another rearing of the man vs. bear debate. Our eternal prison.

so I can't tell you in definite terms what a reasonable suspicion is,

I'm not asking for definite terms, I'm suggesting that women have more experience dealing with men and danger and dangerous men than men do. Men do have a lot of opinions about it, though.

If we're using the example of the hotel room [...] If you start getting into hiding, configuring contraptions, barring the door with chairs,

In the comic, she just engages the deadbolt.

It has been some hours since I last looked at this thread, but I imagine that men are not upset she's being overly cautious, but rather that the comic is suggesting that they—they are taking this personally—are scarier people than women are. They are responding to hurt feelings.