Answering your title question of “is it worth it,” considering that you seemingly either have to compile the app yourself or use an old bloated version with MacPorts, I would probably say “no.” I don’t think the time and difficulty you’d have to potentially go through just to run another file manager when you can’t even truly “replace” Finder is worthwhile.

I’m curious though, what exactly do you want out of Nautilus specifically? You could argue “aesthetic” or something, but that’s just going to look out-of-place on macOS. Unless Nautilus has some hidden superpower somewhere, it’s less functional, too. I could understand Nemo (Cinnamon’s file manager), and I’d definitely consider Dolphin (KDE’s file manager), but Nautilus (to me) has always just been the least powerful file manager with the only advantage being looking native on Adwaita… which wouldn’t even be true if you used it on macOS. Not a criticism, genuine question.