If only it was as innocent as "on and off days". Those statements can be found in this video's first minute. And I hope you're saying "Big Science" satirically as science is not a conglomerate, nor does the worldwide scientific community have any ties to a specific corporate entity/state/nation. And she doesn't "suggest" that "scientific research hasn't delivered as much as it once did", she clearly states that in all fields of science, most of the research paid for by your taxes "is almost certainly bullshit", and that one should not trust scientists. Then after she gets called out for this, she just acts like she was actually only talking about the fundamentals of physics, not every field.

And her defending Eric Weinstein — a man literally directly funded by the Peter Thiel behind the Dark Enlightenment movement — for his pseudoscientific "theory" of everything with obvious fake outrage, saying that "If you take away one thing from this video, let it be that Sabine said Eric's a good and fairly normal person", implying that a theory of everything is something that everyone in her circle has, saying that she hasn't looked into the theory (which is a lie, this gets exposed in the video linked on the original post) and that she "is not interested in unification ideas". Unification in physics by the way is the thing that has been wildly succesful twice and that has allowed her to post her shitty propaganda online. And this is only the first one and a half minutes of that video of hers. As such, I would recommend being skeptical of her opinions on the fundamentals of physics too.

Edit: My apologies if this reply sounds rude or condescending, that was not my intention. It's just a side effect of having to describe people such as Sabine.