I've only done it a few times, but nitrous made me laugh so much, it was great. Nitrous starts fading as soon as you breathe out and is over in 10min tops, but for weed, give yourself an evening to get stoned for the first time. Feeling cramped for time is a huge vibe killer.

Also, modern weed can be way too strong for a first-timer, but if you can find a low-thc/high-cbd strain, you'll have smooth sailing. My poor in-laws hadn't smoked since the 60s, and the budtender sold them a thc vape, good times were not had. Don't make their mistake, haha.

I'd like to offer the counterpoint that someone once advised me not to try weed until after I'd tried LSD, I followed that advice and I think it turned out for the better. There isn't exactly a benefit to being very impressed by the intensity of other drug experiences, and psychedelics can give you a sense of perspective about what you want out of life that's useful for navigating choices. They also tend to be self-deterring; you likely will feel more satisfied and grateful to have your feet on solid ground again after a trip, as opposed to immediately craving more, even if it was wonderful, which is a very convenient property many other drugs lack.