I'll try and answer this but it's complicated...

From what I gather, there are a bunch of different groups that dislike her for different reasons. Some people are just misogynists with fragile egos who can't take a joke. Some are prudes who think less of anyone who does sex work. Some dislike her political comics for being "low effort". Some think her comics are unfairly boosted (bots or something I guess??) to be more prominent than they should be. Some are upset over her apparent misandry in one particular comic (and the doubling down defense of it). And lastly some dislike how much "power" she has to quash all criticism/critique/parody of her comics.

It's messy because the ones in the last couple of groups get lumped in with the ones in the first groups and it gets vitriolic/toxic pretty quickly. You know, like the internet tends to do.