Could literally be talking about billions of people from a period spanning thousands of years.

Not really, from context pretty sure it’s one of those “ex post facto” prophecy things.

This is why people should read books of the Bible and not verse. Random bits out of context are used to imply so much BS.

Now then, I tell you the truth: Three more kings will arise in Persia, and then a fourth, who will be far richer than all the others. When he has gained power by his wealth, he will stir up everyone against the kingdom of Greece. Then a mighty king will arise, who will rule with great power and do as he pleases. After he has arisen, his empire will be broken up and parceled out toward the four winds of heaven. It will not go to his descendants, nor will it have the power he exercised, because his empire will be uprooted and given to others.

The king of the South will become strong, but one of his commanders will become even stronger than he and will rule his own kingdom with great power. After some years, they will become allies. The daughter of the king of the South will go to the king of the North to make an alliance, but she will not retain her power, and he and his power will not last. In those days she will be betrayed, together with her royal escort and her father[ and the one who supported her.

One from her family line will arise to take her place. He will attack the forces of the king of the North and enter his fortress; he will fight against them and be victorious. He will also seize their gods, their metal images and their valuable articles of silver and gold and carry them off to Egypt. For some years he will leave the king of the North alone. Then the king of the North will invade the realm of the king of the South but will retreat to his own country. His sons will prepare for war and assemble a great army, which will sweep on like an irresistible flood and carry the battle as far as his fortress.

None of this is connected to Revelation, which was written centuries later.