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The ISS is 'too clean', and it could be making astronauts sick
(www.abc.net.au)
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I do want to say that you're totally right about space based manufacturing key to any real expansion into space. I mean automated would be nice, but it's not totally necessary. Getting manufacturing to work in space at all is going to take some serious experimentation, so it can't really start 100% automated. But on the other hand, I do expect robotic drones to play a major role, even in the beginning.