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The ISS is 'too clean', and it could be making astronauts sick
(www.abc.net.au)
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Radiation isn't that big a deal. If you have a large enough structure for a colony, or even large enough for 50 people, then you have plenty of mass for radiation shielding. At that scale it's a non-issue.
Well, only at first... Families don't want to live in cramped ships, so they won't. They'll live in artificial habitats with grass and open spaces. Eventually they'll be large enough to have rivers and mountains.
But even without all that, just ask anyone who's served on a submarine if it's possible to survive in cramped quarters. It's doable.