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Here is it illustrated by multiple examples:
The situation with more clients is more nuanced, but essentially the same:
as you can see, the people with open ports have a massive speed advantage in this example, literally getting 9 times the upload speed available in the network. But essentially, torrenting still works as long as some people have open ports, just everyone with closed ports is at a severe disadvantage.
Now there are a couple more issues with closed ports (like DHT/pex not working) but they all boil down to the same problem: the ones with closed ports can only get stuff from people with open ports. Thus they are at a massive disadvantage and get reduced speeds or in contrived situations with few seeders even nothing.