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As a baby I was born with a pituitary issue which meant my hands and feet were abnormally small. They never grew that large at all. I can run and walk fine and they're not deformed or anything, just tiny. I might have some hilarious world record for smallest hands and feet on a fully grown adult! Luckily my condition hasn't affected any other part of my body.
Yes people do notice on at least a weekly basis. The size difference is quite dramatic compared to normal sized shoes. My foot next to a pair of size 9s
And size 10