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submitted 1 year ago* (last edited 1 year ago) by MrSangrief@lemmy.world to c/worldnews@lemmy.ml
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[-] null_@lemmy.world 118 points 1 year ago* (last edited 1 year ago)

There is a lot of public misunderstanding of the rodent studies that linked aspartame to cancer, which are very flawed and essentially come from a single Italian research group.

There is still no definitive link to cancer risk in humans so I would continue to be skeptical. The maximum recommended safe exposure for aspartame is the equivalent of 12 cans of coke, and the strong effects from the rodent study were using exposure amounts equivalent to 5 times that amount, or 60 cans daily, every day of their life after day 12 of fetal life (i.e. before birth).

Almost anything can cause long-term health risks and toxicity at such massive exposure levels.

https://www.cancer.org/cancer/risk-prevention/chemicals/aspartame.html

Link to the free Pubmed link to one of the original source studies from 2008 so you can see their methodology and the absurdly massive exposure amounts needed to ovserve these effects:

https://pubmed.ncbi.nlm.nih.gov/17805418/

[-] Burstar@lemmy.dbzer0.com 34 points 1 year ago* (last edited 1 year ago)

I disagree with the 'massive' exposure 'needed' to observe these effects exaggeration. First, the point of the study was to show it can be carcinogenic, not to parse at exactly what level in humans. Second, effects are seen at the 400ppm level which equates to 20mg/kg. This is 1600mg/day or 8 cans of Diet Coke (@200mg/can) for an 80kg male. That is NOT an impossible level of daily consumption for many.

I suspect further research was done to confirm your linked studies and refine exactly at what minimum levels of daily consumption elicit carcinogenic effects. That will likely be in the full report once released. Until then, you sound like you don't want it to be true, rather than an impartial evaluator of the research.

[-] ruck_feddit@lemmy.ml 8 points 1 year ago

Apple seeds can kill you in large enough quantities

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[-] p03locke@lemmy.dbzer0.com 25 points 1 year ago

the strong effects from the rodent study were using exposure amounts equivalent to 5 times that amount, or 60 cans daily, every day of their life after day 12 of fetal life (i.e. before birth).

This is why I hate rodent studies. They always up the exposure to whatever they are testing to hyper-extreme limits. Then point their flawed results to the world and declare "See! X causes Y!"

There are even similar rat studies for marijuana that try to link it to cancer as well, despite the fact that zero people have actually died from weed. It's all overblown bullshit.

[-] MaxVoltage@lemmy.world 9 points 1 year ago

Dude have you seen how many diet Cokes people drink? Liters and liters daily. Not excessive at all honestly considering LifeTime total exposure

Im a chemist by trade. This is actually chemically very simple. I only looked deeply into Sucralose Splenda. So I'll discuss that

These have Chlorine molecules. A very electrophilic element even in a chemical bond. Meaning it can cause reactions in other molecules very easily. Sucralose has Three Chlorines. If it touches DNA it's bad business man.

I love diet Coke btw lol I could drink 5 gallons right now idk I smoke cigs. But don't sugar coat it

[-] 133arc585@lemmy.ml 16 points 1 year ago* (last edited 1 year ago)

Table salt has more chlorine by mass than sucralose. Moreover, in your body, table salt dissociates into a chlorine ion, whereas in sucralose it's covalently bonded into the molecular structure. That's not to say that it is suddenly nonreactive, but being covalently bonded tempers some of it's electron craving, so to speak. By your logic, table salt should be orders of magnitude more dangerous than sucralose (it's not).

Edit to add: Do you know of any mechanism by which sucralose could cross the nuclear membrane? If not, sucralose isn't going to be touching DNA at all. It could touch some form of RNA in the cytoplasm, which isn't necessarily innocent, but it's not going to be touching the DNA. That means it won't cause long-term genetic changes or damage; any damage it caused would be transitory to the working set of RNA and that damage would be gone when that RNA was processed/destroyed.

[-] Dr_Cog@mander.xyz 15 points 1 year ago

The presence of chlorine does not make a chemical toxic.

Are you a chemist in the sense that you run a drug store?

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[-] else@lemmy.fmhy.ml 22 points 1 year ago

Also note most people are choosing between sugar and aspartame or another sweetener, and sugar is pretty much categorically a health risk for humans.

[-] BarrelAgedBoredom@lemmy.world 11 points 1 year ago

Nail on the head. Aspartame is still better for you than super processed foods loaded with sugar. This reminds me of the big smear campaign against fat that the sugar industry engineered to take the heat off of themselves way back when

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[-] Wildchandelure@lemmy.world 77 points 1 year ago* (last edited 1 year ago)

Misleading title. They're about to declare it as possibly cancerous. Not fully cancerous. And if anything this is just to get even more research into it.

Aspartame is in a lot of things, mainly sodas and gum, but you'd have to consume a lot of the stuff beyond a human limit really.

I do think this may put a dent in sugar free products assuming it gets declared as such.

[-] 133arc585@lemmy.ml 10 points 1 year ago

They’re about to declare it as possibly cancerous. Not fully cancerous.

What do you mean by this? Everything that can cause cancer is declared "possibly cancerous"; it depends on dose and exposure. Nothing is "fully cancerous" for whatever that might even mean. You can be exposed to radiation and either get cancer or not; it depends on the dose. Would you call radiation "possibly cancerous", or "fully cancerous"?

Analagously, most bacteria can cause infections but they don't always in everyone. So to label a bacteria as purely benign or purely dangerous is just as silly as trying to make a distinction between "possibly cancerous" and "fully cancerous".

Aspartame is in a lot of things, mainly sodas and gum, but you’d have to consume a lot of the stuff beyond a human limit really.

And if someone wants to minimize their risk of cancer, they should be able to make informed decisions. Knowing that at particular food-additive has higher-than-baseline chances of causing cancer allows someone with a different risk-aversion profile to make decisions wisely. If you don't mind the incidence rate at the dose you consume it at, that's fine as well. But it is useful to have it be public knowledge if something is potentially cancer-causing.

[-] MooseBoys@lemmy.world 22 points 1 year ago

It means that Aspartame is going to be added to the “Group 2B” classification list. It’s worth noting that “Red Meat” and “Alcohol” are in the much more severe “Group 1” list, so you should probably give up steak and beer before you ditch your favorite diet soda.

[-] whatsarefoogee@lemmy.world 20 points 1 year ago

The difference between "possibly cancerous" and "fully cancerous" is that the former is not confirmed to have the property of causing cancer.

Radiation on the other hand is known to be carcinogenic.

To use your analogy, we know that there are bacteria that cause infections and bacteria that are harmless to humans. Let's say we have bacteria A that is known to cause infection but not always in everyone. Then we have a bacteria B, which is potentially able to cause infection. We don't know for certain that it can, but we also don't know that it can't.

And yes, it's a pretty fucking useless designation, and WHO is wasting everyone's time and causing undue panic. Let's not forget how they completely fucked the world with their atrocious handing of Covid in the early stages of the outbreak.

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[-] s6original@lemmy.world 58 points 1 year ago

I don't think you can put "the" before WHO unless Roger Daltrey approves it.

I worry about a lot of the additives used today. Some products will say "no sugar added" but will include some artificial sweetener that you only see in the fine print.

[-] PunchEnergy@lemmy.dbzer0.com 20 points 1 year ago

Which is no sugar. So wheres the Problem?

[-] RickyRigatoni@lemmy.ml 17 points 1 year ago

I don't like it when my tea is sweet :(

[-] whatsarefoogee@lemmy.world 14 points 1 year ago

So then buy unsweetened tea. We already have a term for things that aren't sweet.

https://www.amazon.com/Pure-Leaf-Unsweetened-Brewed-Calories/dp/B015Z6WJDY/

I seriously don't understand why you want the "no sugar added" label to have factually incorrect requirements.

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[-] LaVacaMariposa@mander.xyz 16 points 1 year ago

No sugar added should mean no sweeteners added, but that's not the case unfortunately.

[-] whatsarefoogee@lemmy.world 24 points 1 year ago

No sugar added usually just means it's full of sugar originally found in the product. A "no sugar added" apple juice will still have an insanely unhealthy amount of sugar.

I don't know why you think it should mean no sweeteners. (most) sweeteners are categorically not sugar. If you want something not sweet, the label you're looking for is "unsweetened".

Besides, sugar is much worse for you than any artificial sweetener.

"Unsweetened" means no sweeteners added. "No sugar added" means no sugars, but maybe other sweeteners.

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[-] Omegamanthethird@lemmy.world 12 points 1 year ago

I worry about the "natural" sugar alternatives. We all know that aspartame is safe, it's been researched about as extensively as it can be. It only starts to be a concern when you're drinking 2 dozen diets sodas daily.

But people give "natural" a pass for some reason.

[-] AlexWIWA@lemmy.ml 10 points 1 year ago

Natural is always good, my cereal has natural uranium for a spicy natural alternative to sugar. It's totally safe.

(For legal purposes, this comment is a joke)

[-] outbound@lemmy.ca 30 points 1 year ago* (last edited 1 year ago)

As a Type II diabetic:

fuck

As a punk:

All I wanted was a Pepsi
Just one Pepsi

*Diet Pepsi contains sucralose, not aspertame, so I guess I'm good (for now)

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[-] Hazzardis@lemmy.world 30 points 1 year ago

Like how cancerous is it? Considering the amount of diet pop my family consumes…I’m kinda worried

[-] Fingerthief@lemmy.world 62 points 1 year ago* (last edited 1 year ago)

I’m pretty sure the last I read about this it was an absurd concentration that showed to potentially cause cancer. Nothing a human could drink in such concentrations.

That being said maybe that’s changed very very recently, I’ll be interested to see what their actual findings are.

A lot of things potentially cause cancer in huge concentrations.

Edit - From what I’ve read aspartame would be considered a possible carcinogen in the same class of Coffee. That doesn’t make quite the same headline though hah!

[-] PunchEnergy@lemmy.dbzer0.com 14 points 1 year ago
[-] CanadaPlus@lemmy.sdf.org 9 points 1 year ago

It doesn't even take that much sunlight really.

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[-] FlowVoid@midwest.social 30 points 1 year ago* (last edited 1 year ago)

It doesn't take much for the WHO to classify something as a possible carcinogen.

Aspartame is now in the same risk category as cell phones, kimchee, and carpentry. And still considered less carcinogenic than meat, fried foods, hot beverages, and working a night shift.

[-] DrinkBoba@lemmy.world 22 points 1 year ago

Not gonna preach or anything but that stuff is trash. You guys should quit honestly. I “reset” my tastes to less sweet stuff over time and it’s incredible how different things taste after you lose the expectations they should be sweet to be delicious.

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[-] fluke@lemmy.world 18 points 1 year ago

Aspartame has been in common usage as a sugar alternative for literally decades.

If it was harmful or potent enough to be dangerous on a public or individual health risk then we would have certainly known about it by now. At this stage, even WHO, are saying it's needed in HUGE concentrations.

Diet sodas aren't the only things that we consume that contains aspartame. And aspartame isn't the only thing we're exposed to that has been linked to cancer and other deseases.

Just get on with life, enjoy what you enjoy in moderation. Don't put too much thought into it otherwise you'll just end up living in fear and avoiding everything.

[-] sweBers@lemmy.fmhy.ml 9 points 1 year ago

That was my gut reaction, but that logic also perpetuated leaded fuel.

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[-] Showroom7561@lemmy.ca 16 points 1 year ago

That will be the most important factor: the quantity needed to be harmful.

If it's the equivalent of 30 cans of diet cola a day, this is a non-issue. They will give those details when they release the report.

[-] whatsarefoogee@lemmy.world 9 points 1 year ago

Not cancerous whatsoever. It's approved for use worldwide and it's one of the most studied additives on the planet.

It has been massively consumed worldwide for many decades, without causing any statistically noticeable increase in cancer rates.

Considering the incredibly negative health impact of sugary drinks, artificial sweeteners probably prevented millions of deaths over the decades they have been used.

Like the other "scary" "it causes cancer" studies, they probably stuffed a rat with its body weight of aspartame and when it developed cancer they figured it's carcinogenic.

Completely disregarding that a can of artificially sweetened coke will have less than 1g of aspartame, which is 0.0002% of average human's bodyweight.

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[-] puppet@lemmy.world 25 points 1 year ago

I could be wrong, and I’m too lazy to Google at the moment, but I swore this was made public information long ago. When I was young, aspartame was being phased out in favor of sucralose. I recall hearing stories about aspartame being banned in other countries as a child.

[-] erre@feddit.win 22 points 1 year ago

Hopefully there's more research done. It doesn't sound like it's "absolutely carcinogenic".

The "radiofrequency electromagnetic fields" associated with using mobile phones are "possibly cancer-causing". Like aspartame, this means there is either limited evidence they can cause cancer in humans, sufficient evidence in animals, or strong evidence about the characteristics.

https://www.reuters.com/business/healthcare-pharmaceuticals/whos-cancer-research-agency-say-aspartame-sweetener-possible-carcinogen-sources-2023-06-29/

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[-] reksas@sopuli.xyz 14 points 1 year ago

Stuff that has been sweetened by it kind of taste like there is something wrong. Yet still it tastes decent enough and much better than stevia. I would rather have option to drink stuff that just outright hasnt been sweetened at all.

[-] AcidOctopus@lemmy.ml 13 points 1 year ago

Embrace water. Become a hydro homie.

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[-] peter@feddit.uk 10 points 1 year ago

I knew it was dodgy, aspartame always gives me a headache

[-] charles@lemmy.world 11 points 1 year ago

You're probably just dehydrated from drinking a small amount of soda instead of a larger amount of water.

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[-] vikinghoarder@infosec.pub 9 points 1 year ago

If they conclude that even a small amount is harmful, inagine the backlash all the soda/food insutry giants will create The food industry is a fearful monster that cares more about profit than health. Now think about that.

[-] watson387@sopuli.xyz 8 points 1 year ago

Dammit… I’ve been drinking that shit every day for years. I actually crave the flavor of it.

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this post was submitted on 08 Jul 2023
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