Discworld work make an incredible series of movies. I think D&D Honor Amongst Theives proves that modern comedy fantasies can work great in a movie format.

My other choice would be House of the Scorpion.

Blood Meridian

I don't think this is impossible to adapt. I don't even think it needs a huge budget. If you could nail the cinematography; be comfortable with long sections w/o dialogue; and resist the urge to re-work the pacing you could have something. Think Barry Lindon(1975) but as an ultra-violent Western.

The Cohen bros. proved that McCarthy can be adapted in this way. Think of the opening scene of "No Country For Old Men"(2007).

The Traveler by John Twelve Hawks.

He is a little fucking nuts but the book is fun.

The Hike by Drew Magary

A book called The Land of Laughs by Jonathan Carroll.

Chung Kuo series by David Wingrove

Fafhrd and the Gray Mouser series by Fritz Leiber

Transmetropolitan

Damsel.

When I heard about the Netflix movie I initially thought it was an adaptation of the book...

At this point, I want a movie adaptation just out of spite to see how much better it would be than the complete trash that netflix thought would make a good original story. I do highly recommend the book, too.

The entire 2001: A Space Odyssey series should be a TV show.

The Megastructure Compendium as an Anthology about life around these massive feats of engineering.

Mountain Man: 10 Books by Keith C. Blackmore. Basically, the Zombie Apocalypse happens and a Dude tries to survive alone, physically, mentally and emotionally while also trying to go on supply runs, running into Zombies and generally trying to stay alive while coping with everything. I think it would be good to have some other zombie-related Series that isn't The Walking Dead.

Expeditionary Force: 18 Books by Craig Alanson. Earth and Humanity are attacked by Hamster Aliens, another alien Race, Lizards, who attack the hamsters saving Earth in the process and then recruiting Humanity into a war on a galactic scale but the Hamsters aren't the real enemy of Humanity. I'm only at the end of the 5th Audiobook but they are great and I would really wish Skippy is voiced by the Audiobook Narrator R.C. Bray in a TV adaption.

Kyralia series: Been a while since I read it but a fantastic series related to magic By Trudi Canavan, I think there are just not enough good Magic-related Shows.

Tales of the Otori: A 5-Book Series by Lian Hearn is set in a fictional feudal Japan. The Main story follows a Boy, Takeo, through his life to avenge his adoptive father and escape the legacy of his biological father. Probably the only series in which I had to put down the book at one point and just had to process what was happening.

V. E. Schwab - the Invisible Life of Adie LaRue would be amazing. Classic cursed immortal living through the ages, but without vampires!

The Grand Tour novels from Ben Bova. All about mankinds spread into the solar system. There are some anachronisms here and there that would need to be ironed out, and plenty of continuity errors to fix, but overall a very exciting series of stories.

House of blades / travelers gate series by will wight.

Surprisingly cool YA / RPG ish without being gamey and too cringe.

Would be a very cool show if not done on CB

Honor Harrington might be good on a big screen in the present political climate. (Female lead plus a cat)

The myth adventures might be right for a different flavor of comedy.