Don't think I've seen anyone mention Oneshot. Amazing little game.

The House in Fata Morgana. Nice thing is that'll it be both sad and happy tears.

It's been a few years and listening to the soundtrack snaps me back. I only wish I could I could play it again for the first time.

Plague Tale (Both games are solid, but 2 was sooooo good)

Telltale Games Walking Dead. Not a game, but a whole series.

Tales, Xenogears

That Dragon, Cancer. Part game, part visual novel.

In Bindinc of Isaac you cry a lot.

But on a more serious note. The Life is Strange series can be very emotional, if you like the style of the games.

Rime is hauntingly beautiful in a way that hits you as it finishes.

Titanfall 2... Goodness that ending had my kiddo misty eyed. As for me, there was dust in my hand room or my allergies were acting up.

Had a quick scroll through and didn't see it anywhere yet, so:

Dear Esther.

Actually, reminds me I should play through it again, it's been a few years.

Death Stranding

Haven't actually played it yet but a video about MOTHER 3 made me cry just talking about the story (not only that but the part where he talked about the story made me a little emotional)

Here is the video btw

You may already know it but Omori was heavily inspired by the mother series and especially Mother 3: https://twitter.com/_omocat/status/1384687971929006080

Mother 3 got me tearing up when I first played it

The most recent one to make me cry was...

"I Was a Teenage Exocolonist"