If it's DOMS, you're pretty much always safe to work out again. Your range of motion might be limited to start, so you absolutely must start slow, but it is good to move. DOMS gets worse immediately when you stop moving, and improves significantly once you've moved around and keep moving. Active recovery like walking, yoga, some other dynamic stretching routine, etc.

I would focus on lower weight and cardio. Get the blood pumping, maybe hit an exercise bike for a bit and see how you feel. If you still have gas in the tank and your soreness alleviates then hit some light weights.

I'm assuming it's your legs that are sore. I'd suggest some light stretching. Very light, don't push. In my experience over stretching is terrible for DOMS. Then go for a walk

It will e difficult, but the only sure fire way I've found to eliminate DOMS is increasing workout frequency.

It's "safe" to work out but you'll want to make sure you aren't compromising your form any due to being sore.

I'd suggest making today a lighter weight workout or just focusing on cardio. Getting your muscles moving will increase the blood flow, which will help speed up getting things back to normal.