The rise of metabolic syndromes is probably going to continue to define the next 50 years of medicine honestly. We have a huge, global rise in T2DM, obesity, high cholesterol/BP/etc. due to many things, but primarily the American, carb rich diet and a sedentary lifestyle. That said, i'm hopeful. We've got lots of new treatments for diabetes and even obesity now with GLP1s(Ozempic and others), as well as efforts to make insulins, glucose monitoring devices, etc. cheaper and more available. This makes diabetes so much easier to manage compared to how it used to be. I really hope Ozempic/Wegovy et. al will help put a dent in obesity, because that's probably the biggest risk factor for all the nasty stuff down the line.