Every CIS man I know reacts to Estrogen like it’s radioactive. The couple times I jokingly offered them some they recoiled like I pulled a knife on them. I’m not sure how someone would test that ethically.

That being said, not every trans woman has a euphoric reaction to estrogen, either. Hormones and our reactions to them are complicated and individualized. I’m mentioning this because it seems like you’re setting yourself up for a massive dose of imposter syndrome if E doesn’t immediately live up to your expectations.

Your gender is still valid regardless of your body’s reaction to HRT. If you start HRT and realize it’s not for you, that’s fine. HRT doesn’t define your gender.

I mean half of cis men are afraid of eating vegetables because they think it will estrogenize them. I would be beyond surprised if any cis men have tried a week of HRT

Closest I can find: supplement huckster/wannabe vampire Bryan Johnson takes 8mg per week of some particular type of “non-feminizing estradiol” which he claims doesn’t affect him in any perceptible way but made rats live 16% longer in some study.

But I just don’t know if we’re gonna be able to track down exactly what we’re looking for. My 2c, everyone I know who takes it had an amazing experience and totally transformed in a positive way, and not just physically. But it is a serious decision, so I get doing as much research as possible first. Wishing you the best of luck!

So there isn't a lot of data on that, but there are many cases of cis women taking testosterone (bodybuilders). The symptoms described in those cases are very similar to untreated biochemical dysphoria in trans women.

My educated but ignorant assumption would be that cis men taking estrogen would be very close to untreated biochemical dysphoria in trans men.

But you have to understand that dysphoria doesn't need to be biochemical. There are instances when trans women take estrogen and end up feeling terrible and stopping. I'm sure there are trans women who do not have any biochemical imbalance and they would experience the same symptoms.

Also I think I remember reading that estrogen was used to lessen the symptoms of covid in men, but that might have been a cheese dream or something.

I bumped into a video a while back of a cis man taking e for a month, that might answer your question somewhat:

https://youtu.be/UjfZth98FUQ

I'm a trans woman. My first couple weeks on HRT I was just very tired and emotionally unstable/grumpy. I never really felt euphoria from it. Overall, estrogen has felt better than testosterone did, but that doesn't need to be the case for someone to be trans femme. I've also met trans men that noted the exact same positive effects when they went on testosterone. Everyone is different, and gender isn't a chemical thing.

I have a picture of me from day 6 on HRT, and its the first picture in recent memory with a smile that reaches my eyes. However I'm only able to conclude that retroactively. The effects are so small and gradual it was difficult to notice the changes during the first week. I didn't feel noticeably different until at least the third or fourth week, but even so normal feels like normal.

You sound trans. You should start HRT. I don't think a limited trial is a good idea. If you're going to go through the effort to obtain the HRT, you should just start it, with the knowledge that you can stop at any time if it doesn't feel right for you.

If you really want to know the effects of HRT on cis men, read into history. HRT was a punishment for homosexuality. Alan Turing was notably sentenced to probation and a year of synthetic estrogen injections. I'm sure there are surviving letters from him and men who underwent that if you're interested in doing research into the topic.

I've read that excess testosterone can be converted into estrogen, but I can't imagine that imbalance would have the same effect as hrt

I don't know if this is a welcome contribution but I'm afab, and was on t briefly. I had to stop because it made me very sick, and I never experienced euphoria from it. That sucked, and it still sucks. My point is, even after not having a good experience with that hormone, I still desire the changes it can give me. My body not tolerating the hormone doesn't mean I'm cis, it's more likely that it means I need a different formulation.